Endocrinology

Hypertension and nephrology

APRIL 30, 2024

[New forays into primary aldosteronism to the article]

[ ]

HUN 2024;28(2)

Hypertension and nephrology

APRIL 30, 2024

[Effect of rilmenidine therapy on heart rate- and blood pressure variability as well as baroreceptor sensitivity]

FINTA Ervin

[The sympathetic nervous system plays an important and widely investigated role in the pathogenesis of the hypertension and its concomitant diseases.]

HUN 2024;28(2)

Hypertension and nephrology

APRIL 30, 2024

[Analysis of the antihypertensive effect of the antihypertensive rilmenidine]

FARSANG Csaba, LENGYEL Mária, BORBÁS Sarolta, ZORÁNDI Ágnes, DIENES Szórádi Bernadett

[The most recent national (MHT 2018) and the latest European guidelines (ESH 2023) (1, 2), diuretics, the calcium antagonists, ACE inhibitors, ARBs, α1-adren- noceptor blockers and ß-blockers, the so-called "centrally acting" imidazoline (I)-1 receptor agonists were also mentioned.]

HUN 2024;28(2)

Hypertension and nephrology

APRIL 30, 2024

[More ramblings in the plethora called primary aldosteronism]

BAJNOK László

[The issue of primary (hyper)aldosteronism (PA) is fraught with many contradictions, attempts to identify it are important but undeservedly rare. The recently introduced histological method with practical benefits indicates a new aspect of the spectrum disease character and a revolutionary study has also been published regarding the functional (radionuclide) imaging of PA.]

HUN 2024;28(2)

Lege Artis Medicinae

APRIL 30, 2024

[The misuse of insulin ]

BUZÁS György Miklós

[Discovered in 1922, insulin has saved millions of lives, and improved the quality of life of diabetic patients: it was and is the mainstay of antidiabetic treatment. Like many discoveries, however, it can also be used incorrectly, causing harm and even death. Attempted or terminated suicide as an important example of insulin misuse must be distinguished from accidental, deliberate or factitious insulin overdoses. With increasing prevalence of diabetes and spreading use of pharmaceutical insulin products, such cases are expected to rise. Regular, human and analogue insulins are used for this purpose. Famous killings by insulin were reported in both scientific and lay literature as reality cases, and achieved high rates of publicity. Insulin shock therapy used in psychiatry and post-vagotomy insulin tests can also have side effects or end up lethally. Insulin and insulin-like growth factor are also applied as drugs for doping. Investigations to prove insulin misuse benefit from the most advanced methods of clinical chemistry. ]

HUN 2024;34(4)

Lege Artis Medicinae

APRIL 30, 2024

[Female aspects of dementia ]

KOVÁCS Tibor

[Dementia is a new epidemic of the 21st century in all aging societies. Besides old age, female sex is one of the non-modifiable risk factors of dementia. Alzheimer’s disease is responsible for two thirds of all dementia cases, two thirds of which are female patients. This female excess is not seen in other degenerative (such as Lewy body or frontotemporal dementia) conditions or vascular dementias. In the background of this additional risk there are primarily hormonal differences suspected. The later developing menopause decreases the risk of dementia. Albeit, the beneficial role of oestrogen seemed to be verified by animal tests and human data, the hormone replacement therapy has not justified the expectations: its outcomes were clearly without benefits in preventing dementia, thus its administration is not recommended in the clinical practice. These contradictory outcomes may be explained by the time window of hormone replacement therapy, which should be explored by further research programs. This study summarises all aspects of female dementia by narrative review of the concerning literature. ]

HUN 2024;34(4)